The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species.

@article{Pani2009ThePS,
  title={The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species.},
  author={Giovambattista Pani and Osvaldo Ra{\`u}l Koch and Tommaso Galeotti},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 5},
  pages={1002-5}
}
Once considered as a mere by-product of respiration, mitochondrial generation of reactive oxygen species (ROS) has recently emerged as a genetically controlled phenomenon, involved in complex intracellular signal transduction cascades that directly regulate cell survival and death in responses to environmental stressors. These cascades are involved in the pathogenesis of several major age-related diseases, such as cancer and neurodegeneration, and also appear to somehow regulate the "normal… CONTINUE READING
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