The p53 orchestra: Mdm2 and Mdmx set the tone.

@article{Wade2010ThePO,
  title={The p53 orchestra: Mdm2 and Mdmx set the tone.},
  author={M. Wade and Yunyuan V. Wang and G. Wahl},
  journal={Trends in cell biology},
  year={2010},
  volume={20 5},
  pages={
          299-309
        }
}
The activities of p53 cover diverse aspects of cell biology, including cell cycle control, apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of p53 function engenders tumor susceptibility, hyperactivation of p53 is lethal. Therefore, p53 activity must be strictly regulated to maintain normal tissue homeostasis. Critical for the control of p53 function are its two main negative regulators: Mdm2 and Mdmx. Recent reports have provided insight into the… Expand

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