The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity.

@article{Mishra2006ThePO,
  title={The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity.},
  author={Suresh Mishra and Liam J. Murphy},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={339 2},
  pages={726-30}
}
Increased expression and activity of the ubiquitous enzyme, tissue transglutaminase (TG2), is consistently seen in a variety of models of apoptosis. The p53 oncoprotein is also involved in apoptosis. Here we investigated the interaction of TG2 with p53 and show that the p53 is a substrate for the recently identified serine/threonine kinase activity of TG2. Phosphospecific antibodies indicated that TG2 phosphorylated p53 at Ser(15) and Ser(20), residues that are critically important in the… CONTINUE READING

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