The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer.

  title={The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer.},
  author={Richard E. Buller and Thomas A. Lallas and Mark S. Shahin and Anil Sood and Melanie A Hatterman-Zogg and Barrie Anderson and Joel I. Sorosky and P Kirby},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={7 4},
PURPOSE Cancer-specific p53 mutational spectra have been identified. Data from murine models and human BRCA1-related hereditary breast cancers suggest that both unique and specific BRCA1-associated p53 mutations may be found in BRCA1-related ovarian cancers. EXPERIMENTAL DESIGN The p53 mutational spectrum from ovarian cancers containing either somatic or germ-line BRCA1 mutations was compared with that of sporadic ovarian cancers defined as those diagnosed with a negative family history for… CONTINUE READING


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