The p53/miR-34 axis in development and disease.

Abstract

The tumor suppressor p53 is one of the most frequently mutated genes in human cancers. MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on the post-transcriptional level. Recently, it was shown that p53 regulates the expression of several miRNAs, thereby representing an important mechanism of p53 signaling. Several independent studies identified the members of the miR-34 family as the most prevalent p53-induced miRNAs. miR-34s are frequently silenced in variety of tumor entities, suggesting that they are important tumor suppressors. Indeed, ectopic expression of miR-34s inhibits proliferation, epithelial to mesenchymal transition, migration, invasion, and metastasis of various cancer cell entities. Moreover, delivery or re-expression of miR-34 leads to notable repression of tumor growth and metastasis in cancer mouse models, and may therefore represent an efficient strategy for future cancer therapeutics. Besides their crucial functions in cancer, members of the miR-34 family also play important roles in spermatogenesis, stem cell differentiation, neuronal development, aging, and cardiovascular functions. Consequently, miR-34 has also been implicated in various non-cancerous diseases, such as brain disorders, osteoporosis, and cardiovascular complications.

DOI: 10.1093/jmcb/mju003

6 Figures and Tables

010020030020132014201520162017
Citations per Year

462 Citations

Semantic Scholar estimates that this publication has 462 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Rokavec2014ThePA, title={The p53/miR-34 axis in development and disease.}, author={Matjaz Rokavec and Huihui Li and Longchang Jiang and Heiko Hermeking}, journal={Journal of molecular cell biology}, year={2014}, volume={6 3}, pages={214-30} }