The p53 family in nervous system development and disease.

  title={The p53 family in nervous system development and disease.},
  author={William Bradley Jacobs and David R Kaplan and F. D. Miller},
  journal={Journal of neurochemistry},
  volume={97 6},
The p53 family, consisting of the tumor suppressors p53, p63 and p73, play a vital role as regulators of survival and apoptosis in the developing, adult and injured nervous system. These proteins function as key survival and apoptosis checkpoints in neurons, acting as either rheostats or sensors responsible for integrating multiple pro-apoptotic and survival cues. A dramatic example of this checkpoint function is observed in developing sympathetic neurons, where a pro-survival and truncated… CONTINUE READING

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