The p53 effector Perp mediates the persistence of CD4+ effector memory T-cell undergoing lymphopenia-induced proliferation.

@article{Zhou2020ThePE,
  title={The p53 effector Perp mediates the persistence of CD4+ effector memory T-cell undergoing lymphopenia-induced proliferation.},
  author={Yan Zhou and Xiao Leng and Chunfen Mo and Qiang Zou and Yifeng Liu and Yantang Wang},
  journal={Immunology letters},
  year={2020}
}
Under lymphopenic conditions, the rapid spontaneous proliferation produces cells that robustly differentiate into effector memory T (TEM) cells, and the aberrant expansion is preferentially driven by self-antigens. The pool size of effector memory T-cell is governed by a complex homeostatic balance between proliferation and death. Perp is a critical effector involved in the p53-dependent apoptotic pathway and widely expressed in mammalian tissues. We have previously shown that Perp has a… Expand
1 Citations
Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity
TLDR
This review summarizes the important roles of lymphopenia/LIP and the Treg cells in various autoimmune conditions, thereby highlighting them as key therapeutic targets for autoimmunity treatments. Expand

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