The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.

@article{Pant2013ThePF,
  title={The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.},
  author={Vinod Pant and Shunbin Xiong and James G Jackson and Sean M. Post and Hussein A Abbas and Alfonso Quint{\'a}s-Cardama and Amirali N Hamir and Guillermina Lozano},
  journal={Genes & development},
  year={2013},
  volume={27 17},
  pages={1857-67}
}
The p53-Mdm2 feedback loop is perceived to be critical for regulating stress-induced p53 activity and levels. However, this has never been tested in vivo. Using a genetically engineered mouse with mutated p53 response elements in the Mdm2 P2 promoter, we show that feedback loop-deficient Mdm2(P2/P2) mice are viable and aphenotypic and age normally. p53 degradation kinetics after DNA damage in radiosensitive tissues remains similar to wild-type controls. Nonetheless, DNA damage response is… CONTINUE READING

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