The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

@inproceedings{Arsic2015ThePI,
  title={The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential},
  author={Nikola Arsic and Gilles Gadea and Ebba Louise Lagerqvist and Muriel Busson and Nathalie Cahuzac and Carsten Brock and Fr{\'e}d{\'e}ric Hollande and V{\'e}ronique Gire and Julie Pannequin and Pierre Roux},
  booktitle={Stem cell reports},
  year={2015}
}
  • Nikola Arsic, Gilles Gadea, +7 authors Pierre Roux
  • Published in Stem cell reports 2015
  • Medicine, Biology
  • Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that Δ133p53β, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. Δ133p53β stimulated the expression of the key pluripotency factors SOX2, OCT3/4, and NANOG. Similarly, in highly metastatic breast cancer cells, aggressiveness was coupled with enhanced CSC potential and Δ133p53β expression. Like in MCF-7 cells, SOX2, OCT3/4… CONTINUE READING

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