The p41 isoform of invariant chain is a chaperone for cathepsin L.

@article{LennonDumnil2001ThePI,
  title={The p41 isoform of invariant chain is a chaperone for cathepsin L.},
  author={Ana-Maria Lennon-Dum{\'e}nil and Rebecca A. Roberts and Karin Valentijn and Christoph Driessen and Herman S Overkleeft and Ann E Erickson and Peter J Peters and Elizabeth K. Bikoff and Hidde L. Ploegh and P Wolf Bryant},
  journal={The EMBO journal},
  year={2001},
  volume={20 15},
  pages={4055-64}
}
The p41 splice variant of major histocompatibility complex (MHC) class II-associated invariant chain (Ii) contains a 65 aa segment that binds to the active site of cathepsin L (CatL), a lysosomal cysteine protease involved in MHC class II-restricted antigen presentation. This segment is absent from the predominant form of Ii, p31. Here we document the in vivo significance of the p41-CatL interaction. By biochemical means and electron microscopy, we demonstrate that the levels of active CatL are… CONTINUE READING

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