The p400 Complex Is an Essential E1A Transformation Target

  title={The p400 Complex Is an Essential E1A Transformation Target},
  author={Miriam Fuchs and Jill D. Gerber and Ronny Drapkin and Said Sif and Tsuyoshi Ikura and Vasily V. Ogryzko and William S. Lane and Yoshihiro Nakatani and David M. Livingston},
Here, we report the identification of a new E1A binding protein complex that is essential for E1A-mediated transformation. Its core component is a SWI2/SNF2-related, 400 kDa protein (p400). Other components include the myc- and p/CAF-associated cofactor, TRRAP/PAF400, the DNA helicases TAP54alpha/beta, actin-like proteins, and the human homolog of the Drosophila Enhancer of Polycomb protein. An E1A mutant, defective in p400 binding, is also defective in transformation. Certain p400 fragments… CONTINUE READING
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