The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit

Abstract

IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 biosynthesis at the posttranscriptional and posttranslational levels were investigated. We show that the combination of RNA/codon-optimized gene sequences and fine-tuning of the relative… (More)
DOI: 10.1074/jbc.M112.436675

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