The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP).

@article{Carter1999ThePM,
  title={The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP).},
  author={Aaron Brent Carter and Kevin L. Knudtson and Martha M. Monick and Gary W. Hunninghake},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 43},
  pages={30858-63}
}
Endotoxin-induced cytokine gene transcription in monocytes and macrophages is regulated in part by NF-kappaB. We have previously shown that the p38 mitogen-activated protein (MAP) kinase is necessary for endotoxin-induced cytokine gene transcription. Due to the fact that most cytokine promoter sequences have active NF-kappaB sites, we hypothesized that the p38 MAP kinase was necessary for NF-kappaB-dependent gene expression. We found that NF-kappaB-dependent gene expression was reduced to near… CONTINUE READING
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