The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation.

Abstract

The invasive phenotype of cancers critically depends on the expression of proteases such as the M(R) 92,000 type IV collagenase (MMP-9). Several growth factors and oncogenes were found to increase promoter activity and as a consequence protease expression. This frequently requires the activation of the transcription factor AP-1 by signal transduction… (More)

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@article{Simn2001ThePS, title={The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation.}, author={Carlos Sim{\'o}n and M. Simon and Goran Vucelic and Martin J. Hicks and P. K. Plinkert and Assen Koitschev and Hans Peter Zenner}, journal={Experimental cell research}, year={2001}, volume={271 2}, pages={344-55} }