The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look

@inproceedings{Clark2012ThePM,
  title={The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look},
  author={A R Clark and Jonathan Dean},
  booktitle={The open rheumatology journal},
  year={2012}
}
The p38 mitogen-activated protein kinase (MAPK) signaling pathway has been strongly implicated in many of the processes that underlie the pathology of rheumatoid arthritis (RA). For many years it has been considered a promising target for development of new anti-inflammatory drugs with which to treat RA and other chronic immune-mediated inflammatory diseases. However, several recent clinical trials have concluded in a disappointing manner. Why is this so, if p38 MAPK clearly contributes to the… CONTINUE READING

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