The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS

@inproceedings{Chung2015ThePM,
  title={The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS},
  author={S-H Chung and Sangita Biswas and Vimal Selvaraj and X Liu and J Sohn and Peng Jiang and C Chen and Fanny Chmilewsky and Havva Marzban and Makoto Horiuchi and David Pleasure and Wenbing Deng},
  booktitle={Cell Death and Disease},
  year={2015}
}
The p38α mitogen-activated protein kinase (MAPK) is one of the serine/threonine kinases regulating a variety of biological processes, including cell-type specification, differentiation and migration. Previous in vitro studies using pharmacological inhibitors suggested that p38 MAPK is essential for oligodendrocyte (OL) differentiation and myelination. To investigate the specific roles of p38α MAPK in OL development and myelination in vivo, we generated p38α conditional knockout (CKO) mice under… CONTINUE READING
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Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination

  • S Hossain, MA de la Cruz-Morcillo, R Sanchez-Prieto, G. Almazan
  • Glia
  • 2012
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