The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

@inproceedings{Tiedje2012ThePE,
  title={The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation},
  author={Christopher Tiedje and Natalia Ronkina and Mohammad Mehdi Tehrani and Sonam Dhamija and Kathrin Laass and Helmut Holtmann and Alexey Kotlyarov and Matthias Gaestel},
  booktitle={PLoS genetics},
  year={2012}
}
TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precursor at the ER requires expression of the ARE-binding and -stabilizing factor human antigen R (HuR) together with either activity of the p38 MAPK/MK2 pathway or the absence of the ARE-binding and… CONTINUE READING

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