The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

@article{Jabbour2002ThePR,
  title={The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis},
  author={Anissa M Jabbour and Paul G Ekert and Elizabeth J. Coulson and Melissa J. Knight and David V. M. Ashley and Christine J Hawkins},
  journal={Cell Death & Differentiation},
  year={2002},
  volume={9},
  pages={1311-1320}
}
This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the P1 residue of this site abolished… CONTINUE READING

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