The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer

@article{Park2018ThePK,
  title={The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer},
  author={Jung Jin Park and Mee-Hee Park and Eun Hye Oh and Nak-Kyun Soung and Soo Jae Lee and Jae-Kyung Jung and Ok-Jun Lee and Seok Joong Yun and Wun-Jae Kim and Eun-Young Shin and Eung-Gook Kim},
  journal={Oncogene},
  year={2018},
  volume={37},
  pages={5147-5159}
}
  • Jung Jin Park, Mee-Hee Park, +8 authors Eung-Gook Kim
  • Published in Oncogene 2018
  • Medicine, Biology
  • Epithelial−mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find that phosphorylated PAK4S474 (pPAK4) levels, an index of PAK4 activation, were tightly associated with Gleason score (p < 0.001), a clinical indicator of PC progression, but not with… CONTINUE READING

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