The p 85 α Regulatory Subunit of Phosphoinositide 3 - Kinase 3 Potentiates JNK - mediated Insulin Resistance 4

Abstract

2 3 Insulin resistance is a defining feature of type 2 diabetes and the metabolic 4 syndrome. While the molecular mechanisms of insulin resistance are multiple, recent 5 evidence suggests that attenuation of insulin signaling by c-Jun N-terminal kinase (JNK) 6 may be a central part of the pathobiology of insulin resistance. Here we demonstrate that 7 the… (More)

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Cite this paper

@inproceedings{Taniguchi2007TheP8, title={The p 85 α Regulatory Subunit of Phosphoinositide 3 - Kinase 3 Potentiates JNK - mediated Insulin Resistance 4}, author={Cullen M. Taniguchi and Jos{\'e} O. Aleman and Kohjiro Ueki and Tomoichiro Asano and Hideaki Kaneto and Gregory N. Stephanopolous and Lewis C. Cantley}, year={2007} }