The ozone paradox: Ozone is a strong oxidant as well as a medical drug

  title={The ozone paradox: Ozone is a strong oxidant as well as a medical drug},
  author={Velio Alvaro Bocci and Emma Borrelli and Valter Travagli and Iacopo Zanardi},
  journal={Medicinal Research Reviews},
After five decades characterized by empiricism and several pitfalls, some of the basic mechanisms of action of ozone in pulmonary toxicology and in medicine have been clarified. The present knowledge allows to understand the prolonged inhalation of ozone can be very deleterious first for the lungs and successively for the whole organism. On the other hand, a small ozone dose well calibrated against the potent antioxidant capacity of blood can trigger several useful biochemical mechanisms and… 
Ozone acting on human blood yields a hormetic dose-response relationship
It is hoped that this gas, although toxic for the pulmonary system during prolonged inhalation, will be soon recognized as a useful agent in oxidative-stress related diseases, joining other medical gases recently thought to be of therapeutic importance.
Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity.
The purpose of this review is to explain the aspects still poorly understood, highlighting the divergent activity of ozone on the various biological districts, and call for a full insertion of ozone therapy within pharmaceutical sciences, responding to all the requirements of quality, efficacy and safety.
Ozone as integrative and complementary support for pharmacological therapy.
  • L. Re
  • Medicine, Biology
    Journal of Ozone Therapy
  • 2021
Ozone could be very helpful as integrative and complementary support for pharmacological therapy modulating the oxidative stress component in many illnesses, elderly and rare diseases, according to not only a legal regulation but also a proper education and training of physicians.
The Clinical Application of Ozonetherapy
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Ozone: A New Therapeutic Agent in Vascular Diseases
It appears necessary to clarify that the use of only a minimal ozone dose and a valid experimental protocol is likely to produce beneficial results, and the need for a well designed, multicenter, clinical trial to be conducted is proposed.
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Mechanisms of action involved in ozone‐therapy in skin diseases
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This study confirms that major autohemotherapy with ozone is safe as far as neutrophil function is concerned, and seems that well-designed clinical trials to assess the efficacy of majorAutohemotherapy would pose no danger to blood cell populations, and should be encouraged.
Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone.
It is shown that ozone (O3) dissolved in the water of either plasma or serum or physiological saline generates reactive oxygen species (ROS), of which hydrogen peroxide (H2O2) can be unequivocally demonstrated by using specific methods for its detection.
The Question of Balance: The Interaction Between Blood and Ozone
This work has shown that appropriate ozone doses are not toxic and elucidated the subtle interaction between the generated compounds and the antioxidant defences, thus restoring the initial antioxidant status.
Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production.
While there is a clear relationship between the ozone dose and IL-8 levels, it is noticed that high TAS and PTG values inhibit the cytokine production, in line with the current idea that hydrogen peroxide, as a byproduct of O3 decomposition, acts as a messenger for the cytokines induction.
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A physicochemical investigation on the effects of ozone on blood.