The oxytocin receptor system: structure, function, and regulation.

@article{Gimpl2001TheOR,
  title={The oxytocin receptor system: structure, function, and regulation.},
  author={G. Gimpl and F. Fahrenholz},
  journal={Physiological reviews},
  year={2001},
  volume={81 2},
  pages={
          629-83
        }
}
The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels. The major site of OT gene expression is the magnocellular neurons of the hypothalamic paraventricular and supraoptic nuclei. In response to a variety of stimuli such as suckling, parturition, or certain kinds of stress, the processed OT peptide is released from the posterior pituitary into the systemic circulation. Such stimuli also lead to an intranuclear release of OT… Expand

Paper Mentions

Observational Patient Registry Clinical Trial
The aim of this study was to assess whether administration of oxytocin intrapartum (Oxt) has any effect on Neonatal Primitive Reflexes (RNP) and if dose dependent. The secondary… Expand
ConditionsBonding, Breastfeeding, Newborn, (+2 more)
InterventionDrug
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TLDR
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References

SHOWING 1-10 OF 744 REFERENCES
Oxytocin Receptors in the Central Nervous System
Specific high-affinity binding sites for oxytocin (OT) are present in the central nervous system. They were first detected by binding studies on plasma membranes isolated from the rat hippocampus.'Expand
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
TLDR
It appears that adequate amounts of vasopressin and oxytocin to induce these effects are released at the appropriate sites of action, and norepinephrine, dopamine, serotonin, and glutamate are the neurotransmitters involved in the influence of the neurohypophyseal hormones and related neuropeptides on brain function. Expand
Structural bases of vasopressin/oxytocin receptor function.
TLDR
Recent studies suggest that the vasopressin V1b receptor may serve additional and unknown functions in the brain and at the periphery, and a great number of molecular probes have been developed, including agonists and antagonists, and radiolabelled, fluorescent or photosensitive ligands. Expand
Ricin‐Cytotoxin Conjugate Administration Reveals a Physiologically Relevant Role for Oxytocin in the Control of Gonadotropin Secretion a
TLDR
It is now apparant that the OT can exert physiologically relevant actions within the anterior pituitary gland to stimulate prolactin (PRL)2J and corticotropin (ACTHr secretion) and to potentiate hypothalamic drive exerted by other releasing factors and, in some unique situations, be the primary releasing factor. Expand
Oxytocin — A neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies
  • T. Insel
  • Biology, Medicine
  • Psychoneuroendocrinology
  • 1992
TLDR
New studies in rat pups demonstrate that central OT selectively decreases the separation response, an effect which mimics social contact, and demonstrate that physiologic changes in gonadal steroids can alter receptor expression in anatomically discrete target fields and thereby direct responsiveness to endogenous neuropeptide release. Expand
Structure, characterization, and expression of the rat oxytocin receptor gene.
TLDR
To study the molecular mechanisms underlying OTR regulation, recombinant bacteriophage lambda EMBL3 genomic clones containing the rat OTR gene are isolated and characterized using sequence information derived from a human myometrial OTR cDNA, supporting the notion that interleukins may mediate labor induction via transcriptional activation of the O TR gene. Expand
The role of sex steroids in the oxytocin hormone system
TLDR
The current consensus suggests that the sex steroids are acting indirectly on both the OT and OTR genes, possibly involving intermediate transcription factors or cofactors, though more study is needed before the few current observations can be generalized. Expand
Oxytocin receptor messenger ribonucleic acid: characterization, regulation, and cellular localization in the rat pituitary gland.
TLDR
Northern blot analysis, reverse transcriptase-polymerase chain reaction, and in situ hybridization analysis indicated a dramatic increase in pituitary OTR gene expression at the end of gestation and after estrogen treatment, suggesting the role of OT as a hypothalamic PRL-releasing factor may so far have been underestimated. Expand
Oxytocin and male reproductive function.
In the male mammal, the small peptide hormone oxytocin is produced in similar quantities within the hypothalamo-pituitary magnocellular system as in the female, yet for the male little is known aboutExpand
Oxytocin receptor-mediated activation of phosphoinositidase C and elevation of cytosolic calcium in the gonadotrope-derived alphaT3-1 cell line.
TLDR
The demonstration that Oxytocin acts directly via PIC-linked, oxytocin-selective receptors to increase cytosolic Ca2+ in a gonadotrope-derived cell line is consistent with the possibility that oxytoc in has a comparable effect on nonimmortalized gonadotropes. Expand
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