The oxytocin-bone axis.

  title={The oxytocin-bone axis.},
  author={Graziana Colaianni and Roberto Tamma and Adriana Di Benedetto and T. K. Yuen and Linlin Sun and M Shoaib Zaidi and Alberta Zambonin Zallone},
  journal={Journal of neuroendocrinology},
  volume={26 2},
We recently demonstrated a direct action of oxytocin (OT) on skeletal homeostasis, mainly mediated through stimulation of osteoblasts (OBs) formation and through the reciprocal modulation of osteoclast (OCs) formation and function. Thus, mice lacking the hormone or its receptor develop a low turnover osteoporosis that worsens with age in both sexes. The skeletons of OT (Ot) and OT receptor (Oxtr) null mice display a pronounced decrease in vertebral and femoral trabecular volume. At the cellular… CONTINUE READING


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