The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.

@article{Dayan2006TheOS,
  title={The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.},
  author={Fr{\'e}d{\'e}ric Dayan and Dani{\`e}le Roux and Marie Christiane Brahimi-Horn and Jacques M. Pouyssegur and Nathalie M. Mazure},
  journal={Cancer research},
  year={2006},
  volume={66 7},
  pages={3688-98}
}
The function of the hypoxia-inducible factor-1 (HIF-1), the key transcription factor involved in cellular adaptation to hypoxia, is restricted to low oxygen tension (pO(2)). As such, this transcription factor is central in modulating the tumor microenvironment, sensing nutrient availability, and controlling anaerobic glycolysis, intracellular pH, and cell survival. Degradation and inhibition of the limiting HIF-1alpha subunit are intimately connected in normoxia. Hydroxylation of two proline… CONTINUE READING
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