The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection.

@article{Kukreja1992TheOF,
  title={The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection.},
  author={Rakesh C. Kukreja and Michael L. Hess},
  journal={Cardiovascular research},
  year={1992},
  volume={26 7},
  pages={
          641-55
        }
}
Highly toxic oxygen radicals and their metabolites have been implicated in the pathogenesis of ischaemia/reperfusion injury. These reactive oxygen species include the superoxide anion, hydrogen peroxide, hydroxyl radical, and singlet oxygen. The central theme of this review is first to discuss the basic mechanisms of free radical generation from various potential sources, to point out and emphasise the growing importance of the role of singlet oxygen, and then to discuss in depth membrane… 
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