The oxidative stress hypothesis of congestive heart failure: radical thoughts.

@article{Mak2001TheOS,
  title={The oxidative stress hypothesis of congestive heart failure: radical thoughts.},
  author={Susanna Mak and Gary E. Newton},
  journal={Chest},
  year={2001},
  volume={120 6},
  pages={
          2035-46
        }
}
There is extensive experimental evidence from in vitro and animal experiments that congestive heart failure (CHF) is a state of oxidative stress. Moreover, in animal models, the development of CHF is accompanied by changes in the antioxidant defense mechanisms of the myocardium as well as evidence of oxidative myocardial injury. This has led to the hypothesis that oxidative stress may be a mechanism of disease progression in CHF. Indeed, many patients consume antioxidant supplements making the… CONTINUE READING
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