The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.

@article{Vanasco2008TheOS,
  title={The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.},
  author={Virginia Vanasco and Mar{\'i}a Cecilia Cimolai and Pablo Evelson and Silvia {\'A}lvarez},
  journal={Free radical research},
  year={2008},
  volume={42 9},
  pages={815-23}
}
The aims of this work were to study the mitochondrial function and to evaluate (a) the oxidative stress in real time in an acute model of endotoxemia and (b) the effect of alpha-lipoic acid (LA, 100 mg/kg) as a therapeutic strategy to be considered. In rats treated with lipopolisaccharide (LPS, 10 mg/kg), a 1.4-fold increase was observed in in situ skeletal muscle chemiluminescence. Experimental sepsis increased oxygen consumption in tissue cubes (1 mm(3)) by 30% for heart and diaphragm and… CONTINUE READING

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