The oxidative modification of low-density lipoproteins by macrophages.

Abstract

1. Mouse resident peritoneal macrophages in culture modified human 125I-labelled low-density lipoprotein (LDL) to a form that other macrophages took up about 10 times as fast as unmodified LDL. The modified LDL was toxic to macrophages in the absence of serum. 2. There was a lag phase of about 4-6 h before the LDL was modified so that macrophages took it up… (More)

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Cite this paper

@article{Leake1990TheOM, title={The oxidative modification of low-density lipoproteins by macrophages.}, author={D. S. Leake and S M Rankin}, journal={Biochemical pharmacology}, year={1990}, volume={39 11}, pages={1743-50} }