The oxidative metabolism of sparteine in the Cuna Amerindians of Panama: absence of evidence for deficient metabolizers.

Abstract

Sparteine sulfate (50 mg) was administered to 170 Cuna Amerindians, 142 of whom were unrelated, and the drug and its dehydrometabolites were determined in the 0- to 12-hour urine samples. The log10 of the metabolic ratio was unimodally, but not normally, distributed and showed the following values: mean -0.21 +/- 0.26, median -0.24, limits -0.73 and 0.76… (More)

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@article{Arias1988TheOM, title={The oxidative metabolism of sparteine in the Cuna Amerindians of Panama: absence of evidence for deficient metabolizers.}, author={Tomas Arias and Lucie Jorge and D. Lee and Renzo J Barrantes and Toshio Inaba}, journal={Clinical pharmacology and therapeutics}, year={1988}, volume={43 4}, pages={456-65} }