The oxidation states of DJ-1 dictate the cell fate in response to oxidative stress triggered by 4-hpr: autophagy or apoptosis?

@article{Cao2014TheOS,
  title={The oxidation states of DJ-1 dictate the cell fate in response to oxidative stress triggered by 4-hpr: autophagy or apoptosis?},
  author={Ji Rong Cao and Meidan Ying and Nan Xie and Guanyu Lin and Rong Dong and Jun Zhang and Hailin Yan and Xiaochun Yang and Qiaojun He and Bo Yang},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 10},
  pages={1443-59}
}
AIM Chemotherapy-induced reactive oxygen species (ROS) not only contribute to apoptosis, but also trigger autophagy. Since autophagy is reported to protect cancer cells from apoptosis, this weakens the therapeutic effect of chemotherapy. This study aimed at identifying the key molecules that determine the cellular response to ROS and, therefore, provide better strategies to increase chemotherapeutic efficiency. RESULTS Increasing concentrations of N-(4-hydroxyphenyl) retinamide (4-HPR… CONTINUE READING

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