The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.

@article{Brogden2001TheOC,
  title={The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.},
  author={Kim A. Brogden and V C Kalfa and Mark R Ackermann and Debra E. Palmquist and Paul B. McCray and Brian F. Tack},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 1},
  pages={
          331-4
        }
}
Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18(31), CAP18(28), CAP18(22), and CAP18(21a) were the most active, with MICs as low as 0.6 microg/ml. Other cathelicidins were less active. In lambs with pneumonia, 0.5 mg of SMAP29 reduced the concentration of bacteria in both… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Activity of cathelicidin peptides against Chlamydia spp.

Antimicrobial agents and chemotherapy • 2005
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 18 references

The lactoperoxidase system functions in bacterial clearance of airways.

American journal of respiratory cell and molecular biology • 2000
View 1 Excerpt

Similar Papers

Loading similar papers…