The overlooked greatwall: a new perspective on mitotic control

@inproceedings{Glover2012TheOG,
  title={The overlooked greatwall: a new perspective on mitotic control},
  author={David M Glover},
  booktitle={Open biology},
  year={2012}
}
The role of the dual specificity protein phosphatase, Cdc25, in activating the cyclin-dependent kinase-cyclin B complex (Cdk1-CycB) by overcoming the inhibitory Wee1 kinase is a long-established principle for mitotic entry. Recently, however, evidence has emerged of a regulatory network that facilitates Cdk1-CycB activity by inhibiting the form of protein phosphatase 2A having a B55 regulatory subunit (PP2A-B55). Here, I review the genetic and biochemical evidence for Greatwall kinase and its… CONTINUE READING
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