The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells.


We have previously reported that primary sinusoidal endothelial cells from the rat liver are highly dependent on VEGF for cell proliferation in in vitro culture. However, even in the presence of VEGF, essentially all the SE cells could not survive longer than 7 days, leading to growth factor-resistant cell death. The death had characteristics typical of… (More)


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