The overdue promise of short tandem repeat variation for heritability.

  title={The overdue promise of short tandem repeat variation for heritability.},
  author={Maximilian Oliver Press and Keisha D. Carlson and Christine Queitsch},
  journal={Trends in genetics : TIG},
  volume={30 11},
Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the heritability of complex traits in humans and model organisms. However, we still struggle to incorporate STR variation into genotype-phenotype maps. We review here the promise of STRs in contributing to complex trait heritability and highlight the challenges that STRs pose due to their repetitive nature. We argue that STR variants are more likely than single-nucleotide variants to have epistatic… CONTINUE READING
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