The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment.

@article{Crpin2014TheOO,
  title={The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment.},
  author={D{\'e}lphine Cr{\'e}pin and Yacir Benomar and Laure Riffault and Hamza Amine and Arieh Gertler and Mohammed Taouis},
  journal={Molecular and cellular endocrinology},
  year={2014},
  volume={384 1-2},
  pages={1-11}
}
Early in life, leptin plays a crucial role in hypothalamic neural organization. Leptin, most likely, controls neural gene expression conferring then specific phenotype regarding energy homeostasis. MicroRNAs are new regulators for several physiological functions, including the regulation of metabolism. However, the impact of leptin on hypothalamic microRNA patterns remains unknown. Here, we demonstrate that miR-200a, miR-200b and miR-429 are up-regulated in the hypothalamus of genetically obese… CONTINUE READING

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