The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF

@inproceedings{Liew2017TheOR,
  title={The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF},
  author={Seng H. Liew and Quynh-Nhu Nguyen and Andreas Strasser and Jock K. Findlay and Karla J Hutt},
  booktitle={Cell death & disease},
  year={2017}
}
In females, germ cells are maintained in ovarian structures called primordial follicles. The number of primordial follicles in the ovarian reserve is a critical determinant of the length of the fertile lifespan. Despite this significance, knowledge of the precise physiological mechanisms that regulate primordial follicle number is lacking. In this study we show that a wave of primordial follicle depletion occurs during the transition to adulthood in mice. We demonstrate that this sudden and… CONTINUE READING