The outer-sphere oxidation of nitrosyliron(II)hemoglobin by peroxynitrite leads to the release of nitrogen monoxide.

@article{Herold2004TheOO,
  title={The outer-sphere oxidation of nitrosyliron(II)hemoglobin by peroxynitrite leads to the release of nitrogen monoxide.},
  author={Susanna Herold},
  journal={Inorganic chemistry},
  year={2004},
  volume={43 13},
  pages={3783-5}
}
It has been suggested that nitrosyliron(II)hemoglobin may represent a form of stabilized NO. and may be responsible for NO. delivery in the peripheral circulation. In this work, we show that NO. can be released from nitrosyliron(II)hemoglobin through reaction with peroxynitrite. Outer-sphere oxidation of the iron center generates nitrosyliron(III)hemoglobin, from which NO. dissociates at a rate of ca. 1 s(-1). The second-order rate constant for the reaction of peroxynitrite with nitrosyliron(II… CONTINUE READING

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