The outer membrane permeability-increasing action of deacylpolymyxins.

@article{Viljanen1991TheOM,
  title={The outer membrane permeability-increasing action of deacylpolymyxins.},
  author={P. Viljanen and Hiromi Matsunaga and Yumiko Kimura and Martti Vaara},
  journal={The Journal of antibiotics},
  year={1991},
  volume={44 5},
  pages={
          517-23
        }
}
The outer membrane permeability-increasing action of deacylpolymyxins was compared to the well-known potent action of polymyxin B nonapeptide (PMBN). Deacylpolymyxin B (DAPB), prepared by treating polymyxin B with polymyxin acylase, was found to be a slightly more effective permeabilizer than PMBN. As low a DAPB concentration as 1 microgram/ml sensitized Escherichia coli to the probe antibiotics (rifampin, fusidic acid, erythromycin, clindamycin, novobiocin) by factors 30-100 and Salmonella… CONTINUE READING

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