The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort

@article{Guzman2015TheOO,
  title={The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort},
  author={Jaime Guzman and Kiem G. Oen and Lori B. Tucker and Adam M. Huber and Natalie J Shiff and Gilles Boire and Rosie Scuccimarri and Roberta A. Berard and Shirley M. L. Tse and Kimberly A. Morishita and Elizabeth Stringer and Nicole Johnson and Deborah M. Levy and Karen Watanabe Duffy and David A. Cabral and Alan M. Rosenberg and Maggie J Larch{\'e} and Paul Dancey and Ross E. Petty and Ronald M. Laxer and Earl D. Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Kristin M. Houghton and Lynn Spiegel and Stuart E. Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne E. Ramsey and Alessandra Bruns and Sarah Campillo and Susanne M. Benseler and Ga{\"e}lle Ch{\'e}deville and Rayfel Schneider and Rae S. M. Yeung and Ciar{\'a}n M. Duffy},
  journal={Annals of the Rheumatic Diseases},
  year={2015},
  volume={74},
  pages={1854 - 1860}
}
Objective To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective inception cohort of children managed with contemporary treatments. Methods Children newly diagnosed with JIA at 16 Canadian paediatric rheumatology centres from 2005 to 2010 were included. Kaplan–Meier survival curves for each JIA category were used to estimate probability of ever attaining an active joint count of 0, inactive disease (no active joints, no extraarticular manifestations and a… Expand

Paper Mentions

Observational Patient Registry Clinical Trial
Juvenile Idiopathic Arthritis (JIA) is a disorder of unknown cause characterized by chronic inflammation of the joints and other organs. It affects about 1 in a 1000 Canadian children… Expand
ConditionsJuvenile Idiopathic Arthritis (JIA)
Interventional Clinical Trial
Far too many kids and families live in dread over the weekly nausea and vomiting caused by methotrexate - a medicine that controls joint swelling in Juvenile Arthritis patients. If… Expand
ConditionsJuvenile Idiopathic Arthritis
InterventionDrug
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TLDR
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To assess short- and long-term outcomes and predictors of juvenile idiopathic arthritis (JIA) children treated with contemporary therapy and compare those with reports elsewhere. Children with JIAExpand
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TLDR
In this cohort, children with polyarticular JIA spent the majority of their follow-up with active disease and children who were RF(+) and children with early evidence of joint damage tended to have a higher prevalence of active disease during the follow- up period. Expand
2-year outcome of juvenile idiopathic arthritis in current daily practice: what can we tell our patients?
TLDR
With current management strategies in daily clinical practice, 77% of newly diagnosed JIA patients achieved a first episode of inactive disease within a median of 10 months, and after 2 years, patients reported moderate functional disability and more than 10% showed radiological evidence of joint damage. Expand
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TLDR
In summary, greater severity/extension of arthritis at onset, symmetric disease, precocious hip/wrist involvement, the presence of rheumatoid factor, and prolonged active disease were the best predictors of a poor outcome. Expand
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TLDR
The present results underline the need to identify early predictors of outcome, to further improve therapy, and to continue long-term followup of patients with JIA. Expand
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TLDR
Clinical measures soon after diagnosis predict short-term outcomes for patients with juvenile idiopathic arthritis, and the JAQQ is a predictor of multiple outcomes. Expand
Complete control of disease activity and remission induced by treatment with etanercept in juvenile idiopathic arthritis.
TLDR
Earlier initiation of treatment, less severe disease, use of at least the recommended weekly dosage of etanercept, and concomitant treatment with MTX seemed to independently increase the chance for reaching remission. Expand
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TLDR
It is observed that only one-fourth of 878 episodes of inactive disease resulted in clinical remission off medication during followup of at least 4 years, highlighting the critical need for therapies that have the ability to induce sustained remission of JIA. Expand
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TLDR
The results indicate that JRA is a disease that often extends into adulthood and functional outcome has improved; however, the estimated rate of arthroplasty remains very high. Expand
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TLDR
There remains a considerable lack of clarity in the prognosis following onset of juvenile idiopathic arthritis for the major outcomes considered, although those with oligoarthritis at presentation have the best outcome. Expand
Juvenile Psoriatic Arthritis: Longterm Outcome and Differentiation from Other Subtypes of Juvenile Idiopathic Arthritis
TLDR
In addition to a history of psoriasis, dactylitis, ankle or toe arthritis, and DRB1*11/12 in children with JIA indicate the likelihood of PsA, a subtype associated with unfavorable outcome, according to a study of outcomes in patients with juvenile psoriatic arthritis. Expand
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