The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.

@article{Haase2011TheOO,
  title={The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.},
  author={Michael Haase and Prasad Devarajan and Anja Haase-Fielitz and Rinaldo Bellomo and Dinna Cruz and Gebhard Wagener and Catherine Dent Krawczeski and Jay L. Koyner and Patrick T. Murray and Michael Zappitelli and Stuart L. Goldstein and Konstantinos Makris and Claudio Ronco and Johan M{\aa}rtensson and C. -R. Martling and Per Venge and Edward D. Siew and Lorraine B. Ware and Talat Alp Ikizler and Peter R. Mertens},
  journal={Journal of the American College of Cardiology},
  year={2011},
  volume={57 17},
  pages={
          1752-61
        }
}
OBJECTIVES The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. BACKGROUND Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. METHODS We analyzed pooled data from 2,322… 
Neutrophil Gelatinase-Associated Lipocalin as a Diagnostic Marker for Acute Kidney Injury in Oliguric Critically Ill Patients: A Post-Hoc Analysis
Background: Oliguria occurs frequently in critically ill patients, challenging clinicians to distinguish functional adaptation from serum-creatinine-defined acute kidney injury (AKIsCr). We
Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL), as an Early Biomarker and Prognostic Factor of Contrast Induced Acute Kidney Injury (CI-AKI) following Cardiac Catheterization
TLDR
Outcome measures were urine NGAL at 4 hrs and serum creatinine at 48 hrs after CAG and patient demographics and procedural factors were although statistically significant in few instances but none was predictive of AKI.
Serum Neutrophil Gelatinase-Associated Lipocalin versus Serum Creatinine for the Prediction of Acute Kidney Injury after Liver Transplantation
TLDR
Serum NGAL concentrations obtained during surgery is a predictor of AKI in patients undergoing LT, and was significantly correlated with the number of units of fresh frozen plasma transfused intra-operatively.
Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status
TLDR
Several studies that collectively strongly support the use of NGAL as a biomarker for the prediction of AKI are identified, however, some limitations are noted, including lack of published studies that adhere to diagnostic study guidelines, heterogeneity in AKI definition, the lack of uniformly applicable cut-off values and variability in the performance of commercially available NGAL assays.
Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients
TLDR
NGAL seems to have reasonable value in predicting use of renal replacement therapy but not mortality, and the heterogeneity in study design and results made it difficult to evaluate the value of NGAL to predict AKI in intensive care patients.
The cardiac surgery-associated neutrophil gelatinase-associated lipocalin (CSA-NGAL) score: A potential tool to monitor acute tubular damage.
TLDR
The CSA-NGAL score might be the tool needed to improve awareness and enable interventions to possibly modify these detrimental outcomes, and is intended to introduce a different approach in study designs, which will undoubtedly expand knowledge and will hopefully move the AKI biomarker field forward.
Predictive Value of Neutrophil Gelatinase-Associated Lipocalin for Contrast-Induced Acute Kidney Injury After Cardiac Catheterization: A Meta-analysis.
TLDR
Urine and serum/plasma NGAL levels appear to be promising biomarkers for early detection of CI-AKI after percutaneous coronary intervention or coronary angiography.
Neutrophil gelatinase-associated lipocalin as early predictor of acute kidney injury after cardiac surgery in adults with chronic kidney failure.
TLDR
Earlier diagnosis of AKI post-surgery based on NGAL assessment makes it possible to initiate appropriate therapy at an earlier stage in this high-risk patient population.
Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences
TLDR
A systematic review of literature data indicates that further studies are necessary to establish accurate reference population values according to age, gender and ethnicity, as well as reliable and specific decisional values concerning the more common clinical settings related to AKI, and suggests that the concept and definition of AKI might need to be reassessed.
Neutrophil Gelatinase-Associated Lipocalin for Acute Kidney Injury During Acute Heart Failure Hospitalizations: The AKINESIS Study.
TLDR
Plasma NGAL was not superior to creatinine for the prediction of WRF or adverse in-hospital outcomes and the use of plasma NGAL to diagnose acute kidney injury in AHF cannot be recommended at this time.
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References

SHOWING 1-10 OF 53 REFERENCES
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis.
TLDR
Age was identified to be an effective modifier of NGAL value with better predictive ability in children and in critically ill patients, and NGAL level was a useful prognostic tool with regard to the prediction of AKI.
The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis.
TLDR
Increased plasma NGAL concentrations measured on presentation to the ED in patients with suspected sepsis were associated with the development of acute kidney injury, and support NGAL as a promising new biomarker for acute kidneys injury is supported.
Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population
TLDR
Plasma NGAL is a useful early marker for AKI in a heterogeneous adult ICU population, in which the timing of renal insult is largely unknown, and it predicts need for RRT and correlates with AKI severity.
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury.
  • A. Haase-Fielitz, R. Bellomo, +6 authors M. Haase
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2009
TLDR
In adult cardiac surgery patients, the predictive value of NGAL increases with grade of AKI, and this observation needs to be taken into account when interpreting any future studies of this biomarker.
Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
TLDR
This study tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort and found that plasma NGAL is an early predictive biomarker of AKI, morbidity, and mortality after pediatric CPB.
Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass.
TLDR
Plasma and urine NGAL thresholds significantly increased in patients with AKI at 2 hours after CPB and remained elevated at all points, with 2-hour NGAL the earliest, strongest predictor of AKI.
Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
IntroductionSerum creatinine is a late marker of acute kidney injury (AKI). Urine neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of AKI, where the timing of kidney injury is
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
TLDR
Univariate analysis showed a significant correlation between acute renal injury and the following: urine and serum concentrations of NGAL at 2 h, and cardiopulmonary bypass time.
Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults.
TLDR
Although a single measurement of uNGAL exhibited moderate predictive utility for the development and severity of AKI in a heterogeneous ICU population, its additional contribution to conventional clinical risk predictors appears limited.
Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury
PurposeTo study the impact of inflammation/sepsis on the concentrations of neutrophil gelatinase-associated lipocalin (NGAL) in plasma and urine in adult intensive care unit (ICU) patients and to
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