The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies.

@article{Farci2000TheOO,
  title={The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies.},
  author={Patrizia Farci and A Shimoda and Alessandra Coiana and Giacomo Diaz and Giovanna Peddis and J C Melpolder and A. Strazzera and David Y. Chien and Santiago J. Munoz and Angelo Balestrieri and Robert H. Purcell and Harvey J. Alter},
  journal={Science},
  year={2000},
  volume={288 5464},
  pages={339-44}
}
The mechanisms by which hepatitis C virus (HCV) induces chronic infection in the vast majority of infected individuals are unknown. Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes. Acute resolving hepatitis was associated with relative evolutionary stasis… CONTINUE READING