The ototoxicity of streptomycin and dihydrostreptomycin.

  title={The ototoxicity of streptomycin and dihydrostreptomycin.},
  author={P. Gillam and J. Archard and B. Dunn},
  volume={46 3},
Summary Seventy-four patients with tuberculosis were divided into two groups, one being treated with 1 g. streptomycin daily and the other with 1 g. of streptomycin-dihydrostreptomycin mixture (streptoduocin). Audiometry was performed before and after treatment. The patients treated with streptomycin had an average of 87 g. (range 16–210 g.) and these treated with streptoduocin 101 g. (range 20–202 g.). Of 36 treated with streptomycin 1 developed tinnitus without audiometric loss and 8 vertigo… Expand
3 Citations
Morphological changes of the vestibular organ by aminoglycosides
In this chapter, changes of the vestibular organ due to intratympanic injection of gentamycin and intraperitoneal injection of streptomycin sulphate are described. Expand
The influence of quinine on the ampullar receptors of the isolated posterior semicircular canal of the frog.
The action of quinine hydrochloride on the ampullar receptors of the isolated posterior semicircular canal has been studied, using electrophysiological methods and the response to stimulation and the spontaneous activity were slightly recovered. Expand
Streptomycin sulphate and deafness: a review of the literature.


Ototoxicity from intermittent streptoduocin therapy of pulmonary tuberculosis; a study of one hundred five patients treated eight to ten months.
In the authors' experience, streptomycin-dihydrostreptomyin combinations seem to offer no advantage over streptomecin alone from the standpoint of ototoxicity when used in the long term treatment of tuberculosis. Expand
Ototoxicity of a mixture of streptomycin and dihydrostreptomycin: a preliminary report.
It is considered that streptomycin in a dosage of 1 gramme daily is likely to cause disabling vestibular symptoms only in older patients, and for these patients the mixture is preferable, and it should be particularly suitable for patients over the age of 40 on ambulant or domicilary antibiotic therapy. Expand
Toxic Effect of Streptomycin upon Balance and Hearing
It is felt that the time has come to reconsider the toxic properties of streptomycin, with special reference to its effect upon the vestibular system, particularly as many of patients have been middle-aged or elderly, when the effect of a disordered vestibULAR system is not easily perceived. Expand
A Comparison of the Toxic and Allergic Reactions Occurring with Streptomycin and Streptoduocin in the Treatment of Pulmonary Tuberculosis
The investigation took place during two consecutive years and patients who completed three months' treatment with either preparation, or in whom treatment had to be stopped because of a reaction, were included in the series. Expand
Dihydrostreptomycin in the treatment of pulmonary tuberculosis with particular reference to its toxicity as compared with that of streptomycin.
In most cases streptomycin has not been considered to be definitive therapy, but rather a very helpful adjunct to other well established methods of treatment, such as bed rest and the various forms of collapse therapy, in patients with tuberculosis. Expand