The other side of the engram: experience-driven changes in neuronal intrinsic excitability

@article{Zhang2003TheOS,
  title={The other side of the engram: experience-driven changes in neuronal intrinsic excitability},
  author={Wei Zhang and David J. Linden},
  journal={Nature Reviews Neuroscience},
  year={2003},
  volume={4},
  pages={885-900}
}
  • W. Zhang, D. Linden
  • Published 1 November 2003
  • Psychology, Medicine
  • Nature Reviews Neuroscience
Modern theories of memory storage have largely focused on persistent, experience-dependent changes in synaptic function such as long-term potentiation and depression. But in addition to these synaptic changes, certain learning tasks produce enduring changes in the intrinsic excitability of neurons by changing the function of voltage-gated ion channels, a change that can produce broader, even neuron-wide changes in synaptic throughput. We will consider the evidence for persistent changes in… Expand
Plasticity of intrinsic excitability
Although modern theories of memory storage have focused on enduring experience-dependent modifications of synaptic efficacy, learning paradigms, as well as patterns of electrical stimulation ofExpand
Plasticity of Intrinsic Excitability as a Mechanism for Memory Storage
Modern theories of memory storage have focused on enduring experience-dependent modifications of synaptic efficacy. However, learning paradigms as well as patterns of electrical stimulation ofExpand
4.40 – Plasticity of Intrinsic Excitability as a Mechanism for Memory Storage
Although modern theories of memory storage have focused on enduring experience-dependent modifications of synaptic efficacy, learning paradigms as well as patterns of electrical stimulation ofExpand
Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
TLDR
In vitro analogs of operant conditioning produced a long-term increase in the excitability of an identified neuron that is critical for the expression of feeding in Aplysia, contributing to the associative modification of the feeding circuitry, providing a mechanism for long- term memory. Expand
Multiple forms of activity‐dependent intrinsic plasticity in layer V cortical neurones in vivo
TLDR
It is demonstrated that neocortical pyramidal neurones can express in vivo a bidirectional use‐dependent intrinsic plasticity, modifying their sensitivity to weak inputs and/or the gain of their input–output function. Expand
Spike timing-dependent plasticity: a Hebbian learning rule.
TLDR
This work has examined the functional consequences of STDP directly in an increasing number of neural circuits in vivo, and revealed several layers of complexity in STDP, including its dependence on dendritic location, the nonlinear integration of synaptic modification induced by complex spike trains, and the modulation ofSTDP by inhibitory and neuromodulatory inputs. Expand
The contribution of ion channels in input-output plasticity
TLDR
It is reviewed here how synaptic input can be efficiently altered by activity-dependent modulation of ion channels that control EPSP amplification, spike threshold or resting membrane potential. Expand
Presumed mechanisms of a long-term increase in the intrinsic excitability of cerebellar granule cells: A model study
Persistent use-dependent changes in the intrinsic neuronal excitability determine the long-term dynamics of the activity of these neurons. In synergy with the long-lasting modification of synapticExpand
Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit
TLDR
Findings have interesting implications for how intrinsic excitability can serve as a neural substrate of learning and memory, and suggest that intrinsic plasticity within specific subpopulations of neurons may promote consolidation of the memory trace in a flexible and efficient manner. Expand
Synergistic excitability plasticity in cerebellar functioning
TLDR
The mechanisms underlying the induction of multiple types of plasticity in cerebellar circuit are introduced and an overview focusing on the plasticity of nonsynaptic intrinsic excitability is given. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 132 REFERENCES
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same
TLDR
Recently, several forms of homeostatic plasticity that stabilize the properties of neural circuits have been identified, and these include mechanisms that regulate neuronal excitability, stabilize total synaptic strength, and influence the rate and extent of synapse formation. Expand
Activity-dependent changes in the intrinsic properties of cultured neurons.
TLDR
The data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation. Expand
Long-Lasting Increases in Intrinsic Excitability Triggered by Inhibition
TLDR
Firing rate potentiation is a novel form of cellular plasticity that could contribute to motor learning in the vestibulo-ocular reflex and may serve as a complementary mechanism to synaptic plasticity. Expand
The Return of the Spike Postsynaptic Action Potentials and the Induction of LTP and LTD
. Formulated to ex- renewed interest in postsynaptic spiking and synapticplain how memories could be stored as alterations in plasticity and have refocused attention on the literalsynaptic strength,Expand
The role of dendritic filtering in associative long-term synaptic plasticity.
TLDR
It is suggested here that both spike train attenuation in the dendrite and its modulation by neurotransmitters and electrical activity may have important functional consequences on the magnitude and/or the sign of the synaptic plasticity induced by a Hebbian pairing procedure. Expand
Rapid, synaptically driven increases in the intrinsic excitability of cerebellar deep nuclear neurons
TLDR
It is demonstrated that neurons of the cerebellar deep nuclei can show persistent increases in their intrinsic excitability following a Ca2+ load imposed by synaptic activation of NMDA receptors or direct current injection. Expand
Hebb and homeostasis in neuronal plasticity
TLDR
It is suggested that Hebbian and homeostatic plasticity often target the same molecular substrates, and have opposing effects on synaptic or neuronal properties, and significantly broaden the framework for understanding the effects of activity on synaptic function and neuronal excitability. Expand
Non-Associative Learning and Serotonin Induce Similar Bi-Directional Changes in Excitability of a Neuron Critical for Learning in the Medicinal Leech
TLDR
The observed changes in postsynaptic excitability appear to contribute to non-associative learning, and modulatory neurotransmitters, such as serotonin, evidently help regulate excitability. Expand
Graded persistent activity in entorhinal cortex neurons
TLDR
It is shown that individual neurons from layer V of the entorhinal cortex—which link the hippocampus to extensive cortical regions—respond to consecutive stimuli with graded changes in firing frequency that remain stable after each stimulus presentation, which constitutes an elementary mechanism for working memory. Expand
BDNF regulates the intrinsic excitability of cortical neurons.
TLDR
It is shown that exogenous BDNF prevented, and a TrkB-IgG fusion protein reproduced, the change in pyramidal neuron excitability produced by activity blockade, suggesting that BDNF may be the signal controlling a coordinated regulation of synaptic and intrinsic properties aimed at allowing cortical networks to adapt to long-lasting changes in activity. Expand
...
1
2
3
4
5
...