The other side of the engram: experience-driven changes in neuronal intrinsic excitability

  title={The other side of the engram: experience-driven changes in neuronal intrinsic excitability},
  author={Wei Zhang and David J. Linden},
  journal={Nature Reviews Neuroscience},
Modern theories of memory storage have largely focused on persistent, experience-dependent changes in synaptic function such as long-term potentiation and depression. But in addition to these synaptic changes, certain learning tasks produce enduring changes in the intrinsic excitability of neurons by changing the function of voltage-gated ion channels, a change that can produce broader, even neuron-wide changes in synaptic throughput. We will consider the evidence for persistent changes in… 

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