The other side of the coin: the protective role of the TH2 cytokines.

@article{Finkelman2001TheOS,
  title={The other side of the coin: the protective role of the TH2 cytokines.},
  author={Fred D. Finkelman and Joseph J. Urban},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={107 5},
  pages={772-80}
}
Although T(H)2 cytokine involvement in allergy makes these cytokines attractive therapeutic targets, they protect against ectoparasites and gastrointestinal worms and suppress inflammation induced by T(H)1 cytokines. T(H)2 cytokines induce mastocytosis, eosinophilia, IgE synthesis, and mucus production. Each element of this response protects against some worms; however, different worms are protected against by different elements of the total response. The induction of the entire response by… CONTINUE READING