The other face of restriction: modification-dependent enzymes

@inproceedings{Loenen2014TheOF,
  title={The other face of restriction: modification-dependent enzymes},
  author={Wil A. M. Loenen and Elisabeth A Raleigh},
  booktitle={Nucleic acids research},
  year={2014}
}
The 1952 observation of host-induced non-hereditary variation in bacteriophages by Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that glucosylate hydroxymethylcytosine in T-even phages and of genes encoding corresponding host activities that restrict non-glucosylated phage DNA: rglA and rglB (restricts glucoseless phage). In the 1980's, appreciation of the biological scope of these activities was dramatically expanded with the demonstration that plant and… CONTINUE READING
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