The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure.

  title={The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure.},
  author={H. Kalervo. V{\"a}{\"a}n{\"a}nen and Meredith Horton},
  journal={Journal of cell science},
  volume={108 ( Pt 8)},
Bone turnover depends upon the balance of bone formation and bone resorption, which is carried out by two separate cell types, osteoblasts and osteoclasts (for review see e.g. Rifkin and Gay, 1992; Väänänen, 1993). Osteoblasts are specialized bone forming cells, which synthesize bone matrix, regulate its mineralization and finally differentiate to mature bone cells, osteocytes. The only cells which have been shown so far to be able to destroy mineralized bone under physiological conditions are… CONTINUE READING


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