The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.

  title={The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.},
  author={Amanda Littlewood-Evans and Graeme Bilbe and Wayne B Bowler and David Farley and Brenda Wlodarski and Toshio Kokubo and Takeshi Inaoka and J R Sloane and Dean B. Evans and James A. Gallagher},
  journal={Cancer research},
  volume={57 23},
Human cathepsin K is a novel cysteine protease previously reported to be restricted in its expression to osteoclasts. Immunolocalization of cathepsin K in breast tumor bone metastases revealed that the invading breast cancer cells expressed this protease, albeit at a lower intensity than in osteoclasts. In situ hybridization and immunolocalization studies were subsequently conducted to demonstrate cathepsin K mRNA and protein expression in samples of primary breast carcinoma. Expression of… CONTINUE READING
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