The osteoblast-heparan sulfate axis: control of the bone cell lineage.

  title={The osteoblast-heparan sulfate axis: control of the bone cell lineage.},
  author={Simon M Cool and Victor Nurcombe},
  journal={The international journal of biochemistry & cell biology},
  volume={37 9},
During osteogenesis, mesenchymal stem cells are recruited to the osteoblast lineage and progressively differentiate into osteoblasts that produce a mineralised extracellular matrix. Although most of the organic component of this matrix is comprised of collagen, growing evidence suggests the most bioactive element of a developing matrix is its heparan sulfate glycosaminoglycan complement. This species of linear, unbranched sugars contain protein-binding domains that regulate the flow of an… CONTINUE READING
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