The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways.

@article{Hirose1995TheOR,
  title={The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways.},
  author={Tetsuro Hirose and Rainer Apfel and Magnus Pfahl and Anton M Jetten},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={211 1},
  pages={83-91}
}
Recently, we reported the cloning and characterization of the novel orphan receptor TAK1. In this study, we analyze the interaction of TAK1 with a variety of response elements (RE's) and demonstrate that TAK1 binds effectively to RE's composed of the core motif PuGGTCA configured in direct repeats spaced by one or more nucleotides. TAK1 bound poorly to palindromic or inverted palindromic motifs and was unable to bind to a single core motif, suggesting that a dimeric site is required for binding… CONTINUE READING
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