The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.

@article{Fontaine2003TheON,
  title={The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.},
  author={Coralie Fontaine and Guillaume Dubois and Yannick Duguay and Torben Helledie and N Vu-dac and Philippe P. Gervois and Fabrice Soncin and S Mandrup and J. -C. Fruchart and Jamila Fruchart-Najib and Bart Staels},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 39},
  pages={37672-80}
}
Rev-Erbalpha (NR1D1) is an orphan nuclear receptor encoded on the opposite strand of the thyroid receptor alpha gene. Rev-Erbalpha mRNA is induced during adipocyte differentiation of 3T3-L1 cells, and its expression is abundant in rat adipose tissue. Peroxisome proliferator-activated receptor gamma (PPARgamma) (NR1C3) is a nuclear receptor controlling adipocyte differentiation and insulin sensitivity. Here we show that Rev-Erbalpha expression is induced by PPARgamma activation with… CONTINUE READING

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